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First Human Study Links 'Forever' Chemicals in Cookware to Liver Cancer

There is evidence that regular exposure to man-made 'permanent' chemicals used in various household products increases the incidence of cancer. increasing.

A new study examining correlations between liver cancer and the presence of these chemicals in humans found that the person with the highest exposure levels had a 350% chance of eventually developing the disease. It turned out to be expensive.

The term "forever" chemicals refers to over 4,700 available types of perfluoroalkyl and polyfluoroalkyl substances, or PFASs, and is widely used in manufacturing. It is so named because the substance breaks down very slowly and accumulates over time. ,in soil,drinking water and the human body.

PFAS was first introduced in the 1930s as a revolutionary material used to create nonstick cookware — hello, Teflon — and soon found itself in all sorts of products and packaging. — from construction tocosmetics materials — as noted by the Centers for Disease Control and Preventionbenefit from its liquid and fire resistant properties receive.

Sausage cooking
Getty Images/iStockphoto

While very useful, such chemicals associated with onset. Effects of cancer and other diseases in experimental animals. In 2006, the Environmental Protection Agency ordered eight multinational manufacturing companies representing the United States to clarify their use. of such chemicals. Nevertheless, as their nicknames indicate, PFOS and his PFOA are still detected in foreign products, groundwater , and people.

"It builds on existing research, but goes a step further," said Jesse Goodrich, a postdoctoral public health researcher at Keck College of Medicine.. A Southern California news release. “Liver cancer is one of the most serious endpoints of liver disease, and this is the first human study to show that PFAS are associated with this disease.

Showing a link between PFAS and cancer in humans has not been easy for scientists. "One of the reasons she has so few studies done in humans is because we need a good sample," added Veronica Wendy Setiawan, M.D., of Keck College of Medicine. "If you're looking at environmental exposures, you need samples from well before diagnosis because cancer takes time to develop."

To make this leap, researchers are Access to a multi-ethnic cohort study database is now available. This included studies of cancer incidence in her more than 200,000 residents of Hawaii and Los Angeles, California, conducted by the University of California. Hawaii.

Their study was narrowed down to his 100 study participants, of whom 50 had liver cancer and 50 did not, sufficient for analysis. No blood and tissue samples were available. Researchers were looking for traces of "permanent" chemicals in the bodies of a group of cancer patients before they got sick.

They reportedly found several types of his PFAS among the participants, with PFOS being most prominent in the liver cancer group. are appearing. In fact, their study revealed that people in the top 10% of PFOS exposures were 4.5 times more likely to develop hepatocellular carcinoma compared to those with the lowest exposures.

The clear link between PFAS and cancer in humans is important for further study of how these chemicals interfere with biological processes. According to current findings, USC scientists now believe that high levels of PFOS in some subjects impair the liver's ability to metabolize glucose, bile acids, and branched-chain amino acids, leading to unhealthy levels of fat in the organ. I think it causes accumulation. - Alcoholic fatty liver disease - a risk factor for liver cancer.

It is no coincidence that many scientists believe that the emergence and widespread use of "forever" chemicals is correlated with an increase in liver disease, cancer,and other diseases..

"Our study explores the long-term health effects of these chemicals on human health, particularly on normal liver function." We think it provides important insight into what it does," Chatzi said. "This study fills an important gap in our understanding of the true consequences of exposure to these chemicals."